Compounds for Alzheimer's disease

US9034871B2 · kind B2 · utility

Assignee

• John Manfredi · US

Inventors

• Rachel Slade · Salt Lake City, US
• Yevgeniya Klimova · Sandy, US
• Robert J. Halter · Salt Lake City, US
• Ashantai J. Yungai · Salt Lake City, US
• Warren S. Weiner · Salt Lake City, US
• Ruth J. Walton · Bountiful, US
• Jon Adam Willardsen · Sandy, US
• Mark B. Anderson · Salt Lake City, US
• Kenton Zavitz · Salt Lake City, US

Key dates

• Filing date: Apr 13, 2012
• Grant date: May 19, 2015
• Expiry date: Apr 17, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel compounds useful for the treatment of neurodegenerative disorders including Alzheimer's disease and dementia. The compounds have a substituents chosen from -L-C(═O)OH, -L-CH═CHC(═O)OH, -L-C(═O)NH2, -L-C(═O)NH(C1-3 alkyl), -L-C(═O)N(C1-3 alkyl)2, -L-S(═O)2(C1-3alkyl), -L-S(═O)2NH2, -L-S(═O)2N(C1-3 alkyl)2, -L-S(═O)2NH(C1-3 alkyl), -L-C(═O)NHOH, -L-C(═O)CH2NH2, -L-C(═O)CH2OH, -L-C(═O)CH2SH, -L-C(═O)NHCN, -L-NHC(═O)ORo, -L-C(═O)NHRo, -L-NH(C═O)NHRo, -L-C(═O)N(Ro)2, -L-NH(C═O)N(Ro)2, -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.