Derivate, preparation method and use of 10-methoxycamptothecin

US9034894B2 · kind B2 · utility

Assignee

• NORTHEAST FORESTRY UNIVERSITY · CN

Inventors

• Yang Wang · Kingston, CA
• Xiufeng Yan · Xing'an, CN
• Lijia Jing · Xing'an, CN
• Weimin Ding · Xing'an, CN
• Jian Zheng · 流花街道, CN
• Qiuying Pang · Xing'an, CN
• Tao Yu · Shanghai, CN

Key dates

• Filing date: Jun 15, 2012
• Grant date: May 19, 2015
• Expiry date: Jun 15, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided is a 10-methoxycamptothecine derivate of formula (1), wherein R is selected from hydrogen, C1-6 alkyl, C1-6 haloalkyl, aryl substituted C1-6 alkyl, phosphate substituted C1-6 alkyl, amino-substituted C1-6 alkyl, carboxyl substituted C1-6 alkyl, hydroxyl substituted C1-6 alkyl, and amide-substituted C1-6 alkyl; R1 is selected from hydrogen and t-butoxycarbonyl substituted amino. Also provided in the present invention are the preparation method of the derivate and the use thereof in anti-tumor drug preparation.