Multi-modality nanoparticles having optically responsive shape

US9037214B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Fanqing Frank Chen · Moraga, US
• Louis Bouchard · Los Angeles, US

Key dates

• Filing date: Feb 23, 2010
• Grant date: May 19, 2015
• Expiry date: May 23, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2991
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In certain embodiments novel nanoparticles (nanowontons) are provided that are suitable for multimodal imaging and/or therapy. In one embodiment, the nanoparticles include a first biocompatible (e.g., gold) layer, an inner core layer (e.g., a non-biocompatible material), and a biocompatible (e.g., gold) layer. The first gold layer includes a concave surface that forms a first outer surface of the layered nanoparticle. The second gold layer includes a convex surface that forms a second outer surface of the layered nanoparticle. The first and second gold layers encapsulate the inner core material layer. Methods of fabricating such nanoparticles are also provided.