Systems and methods for dynamic imaging of tissue using digital optical tomography

US9037216B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Andreas H. Hielscher · Brooklyn, US
• Yang Li · 丈亭镇, CN
• Andres Bur · New York, US
• Molly Lara Flexman · New York, US
• James Masciotti · Germantown, US
• Christopher J. Fong · Elk Grove, US

Key dates

• Filing date: Jul 8, 2010
• Grant date: May 19, 2015
• Expiry date: Feb 7, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/7225
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A methods for imaging tissue using diffuse optical tomography with digital detection includes directing at the tissue a plurality of amplitude modulated optical signals from a plurality of optical signal sources illuminating the tissue at a plurality of locations; detecting a resulting plurality of attenuated optical signals exiting the tissue to obtain a plurality of analog signals containing diffuse optical tomographic information; converting the analog signals into digital signals; recovering the tomographic information from the digital signals using a digital signal processor-based detection module that performs digital detection, wherein the detection module includes a master digital signal processing subsystem and at least one slave digital signal processing subsystem that processes at least a portion of the digital signals and the master digital signal processing subsystem controls the at least one slave digital signal processing subsystem; and transmitting the recovered tomographic information in digital form to a host computer.