Microfluidic devices with removable cover and methods of fabrication and application
US9039997B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 29, 2010 |
| Grant date | May 26, 2015 |
| Priority date | — |
| Expiry date | Apr 14, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N1/405
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.