Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
US9040032B2 · kind B2 · utility
24Cited by
16References
51Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 27, 2012 |
| Grant date | May 26, 2015 |
| Priority date | — |
| Expiry date | Nov 27, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an opioid prodrug that provides enzymatically-controlled release of an opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the opioid from the opioid prodrug so as to attenuate enzymatic cleavage of the opioid prodrug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.