Polynucleotides for use in medicine

US9040238B2 · kind B2 · utility

Assignee

• Max-Delbrück-Centrum Für Molekulare Medizin (MDC) Berlin-Buch · DE

Inventors

• Michael Gotthardt · Berlin, DE
• Norbert Hübner · Berlin, DE
• Marion Lewis Greaser · Middleton, US
• Wei Guo · Shanghai, CN

Key dates

• Filing date: Jun 22, 2010
• Grant date: May 26, 2015
• Expiry date: Mar 16, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2535/131
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a P641L mutation for a rat polypeptide RBM20, b) polynucleotides with a reverse complementary sequence of the polynucleotide of a) above, and c) polynucleotides with an identity at least 50% to a polynucleotide of a) or b) above.