Pan-kinase activation and evaluation of signaling pathways
US9040249B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Oct 31, 2012 |
| Grant date | May 26, 2015 |
| Priority date | — |
| Expiry date | Oct 31, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/573
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and reagents are provided for determining the activation state of a signal transduction pathway signaling protein. There exists a need in the art for methods that can monitor the efficacy of a signal transduction inhibitor in a patient. Other needs exist for detecting and monitoring certain disease or disorders that are associated with aberrant activation of a signal transduction pathway signaling protein. The present assay provides a highly sensitive assay that is also useful in patient populations in which obtaining a large cellular sample is difficult, for example, neonates.
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