Synthetic analogues of neural regeneration peptides

US9040485B2 · kind B2 · utility

Assignee

• CURONZ HOLDINGS COMPANY LIMITED · NZ

Inventors

• Paul William Richard Harris · Richmond, US
• Margaret Ann Brimble · Auckland, NZ
• Frank Sieg · Auckland, NZ

Key dates

• Filing date: Oct 15, 2012
• Grant date: May 26, 2015
• Expiry date: Oct 15, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2892
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of this invention include synthetic compounds (NRP analogues) of peptides termed neural regeneration peptides (NRPs). NRP analogues are made by substituting amino acids in the native peptide sequence, modifying amino acids chemically, by replacing amino acids with synthetic moieties, by stabilizaing β-turns, acetylation of terminal glycine residues or by cyclization. NRP analogues can be used to treat a variety of conditions involving degeneration of neural cells, and includes treating disorders of the nervous system, including peripheral neuropathy, multiple sclerosis, diabetic peripheral neuropathy, neurotoxin-induced neurodegeneration, and amyotrophic lateral sclerosis.