Process for the preparation of chiral triazolones

US9040539B2 · kind B2 · utility

Assignee

• Sandoz AG · CH

Inventors

• Michael Oberhuber · Bolzano - Bozen, IT
• Joerg Salchenegger · Kundl, AT
• Dominic De Souza · Regau, AT
• Martin Albert · Brixlegg, AT
• Thorsten Wilhelm · Kundl, AT
• Martin Langner · Kundl, AT
• Hubert Sturm · Innsbruck, AT
• Hans-Peter Spitzenstaetter · Brixlegg, AT

Key dates

• Filing date: May 18, 2011
• Grant date: May 26, 2015
• Expiry date: May 18, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y3—NH2; of formula (IIa) 0=C═N—Y0 and/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).