Enhanced delivery of immunosuppressive drug compositions for pulmonary delivery

US9044391B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Robert O. WILLIAMS, III · Austin, US
• Keith P. Johnston · Austin, US
• Prapasri Sinswat · Austin, US
• Jason Thomas McConville · Albuquerque, US
• Robert Talbert · San Antonio, US
• Jay I. Peters · San Antonio, US
• Alan B. Watts · Plainsboro, US
• True L. Rogers · Midland, US

Key dates

• Filing date: Jan 10, 2008
• Grant date: Jun 2, 2015
• Expiry date: Mar 4, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.