Chemical conjugates for targeted degradation under reducing conditions
US9044515B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 6, 2012 |
| Grant date | Jun 2, 2015 |
| Priority date | — |
| Expiry date | Nov 2, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6903
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is related to compositions which can undergo targeted degradation under certain physiological reducing conditions. The compositions may, for example, be hydrogels in which maleimide-functionalized low molecular weight heparin is cross-linked with various thiol-functionalized polyethylene glycol multi-arm star polymers. Both the gelation and degradation of the hydrogels can be modified by careful selection of the thiol. For example, hydrogels prepared from aryl thiol-maleimide adducts can undergo a retro Michael addition-type reaction, leading to degradation of the composition and release of the bioactive molecule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.