Glycine transporter-1 inhibitors, methods of making them, and uses thereof

US9045445B2 · kind B2 · utility

Assignee

• ALBANY MOLECULAR RESEARCH, INC. · US

Inventors

• Christopher Cioffi · Troy, US
• Mark Allan Wolf · Williamsville, US
• Peter R. Guzzo · Niskayuna, US
• Shuang Liu · Schenectady, US
• Kashinath Sadalapure · Kalaburagi, IN

Key dates

• Filing date: Jun 2, 2011
• Grant date: Jun 2, 2015
• Expiry date: May 29, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compounds of the present invention are represented by the following formula (I):wherein the substituents R1, R2, R3, R4, (R5)m, R6, A, X, and Y are as defined herein. The compounds are useful in methods of treating a disorder which is created by or is dependent upon inhibiting GlyT-1.