Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease

US9045486B2 · kind B2 · utility

Assignees

• Savira pharmaceuticals GmbH · AT
• European Molecular Biology Laboratory · DE
• F. Hoffmann-La Roche AG · CH

Inventors

• Andrea Wolkerstorfer · Wien, AT
• Oliver Szolar · Wien, AT
• Norbert Handler · Wien, AT
• Helmut Buschmann · Walheim, DE
• Stephen Cusack · Seyssinet-Pariset, FR
• Mark Smith · Saffron Walden, GB
• Sung-Sau So · Verona, US
• Ronald Charles Hawley · Oakland, US
• Achyutharao Sidduri · Newark, US
• Zhuming Zhang · Fryeburg, US

Key dates

• Filing date: Jan 7, 2014
• Grant date: Jun 2, 2015
• Expiry date: Jan 7, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof,which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.