Thienyl [3,2-D] pyrimidin-4-one compounds, preparation method, pharmaceutical compositions and use thereof

US9045491B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• CISEN PHARMACEUTICAL CO., LTD · CN

Inventors

• Hong Liu · Shanghai, CN
• Jia-He Li · Cockeysville, US
• Jian Li · Shanghai, CN
• Jingya Li · Gothenburg, SE
• Jiang Wang · Shanghai, CN
• Mingbo Su · Shanghai, CN
• Jie Lian · Nanjing, CN
• Hualiang Jiang · Shanghai, CN
• Kaixian Chen · Shanghai, CN

Key dates

• Filing date: Oct 23, 2012
• Grant date: Jun 2, 2015
• Expiry date: Oct 23, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are new thienyl [3,2-d] pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.