Processes and intermediates in the preparation of morphine analogs via N-demethylation of N-oxides using cyclodehydration reagents
US9045497B1 · kind B1 · utility
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Key dates
| Filing date | Jan 7, 2015 |
| Grant date | Jun 2, 2015 |
| Priority date | — |
| Expiry date | Jan 7, 2035 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.