Methods for producing amino-substituted glycolipid compounds
US9045514B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 20, 2011 |
| Grant date | Jun 2, 2015 |
| Priority date | — |
| Expiry date | May 9, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/524
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of preparing a compound of formula (I): wherein: a first group selected from R1, R2 and R3 is an amino- or N-acylamino monosaccharide moiety, the acyl group having 1 to 6 carbon atoms, or an oligosaccharide chain comprising 2 to 4 monosaccharide moieties, at least one of which is an amino- or N-acylamino monosaccharide moiety; a second group selected from R1, R2 and R3 is a alkanoyl and alkenoyl acyl group having 3 to 40 carbon atoms; and a third group selected from R1, R2 and R3 is hydrogen, the method comprising contacting a monoacylglycerol, the acyl moiety thereof being a saturated or unsaturated acyl group having 3 to 40 carbon atoms, or an activated derivative thereof, with a source of amino- or N-acylamino monosaccharide moiety, or an activated derivative thereof, and, if required, a source of unsubstituted monosaccharide moiety, or an activated derivative thereof, optionally in the presence of a suitable catalyst or activating agent, is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.