Small molecule conjugates with dimetal species for protein inhibition
US9045527B2 · kind B2 · utility
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Key dates
| Filing date | Jun 12, 2013 |
| Grant date | Jun 2, 2015 |
| Priority date | — |
| Expiry date | Aug 7, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/107
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and the protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.