Immunokinases

US9045739B2 · kind B2 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Stefan Barth · Roetgen, DE
• Mehmet Kemal Tur · Gießen, DE
• Michael Stöcker · Aachen, DE
• Rainer Fischer · Monschau, DE

Key dates

• Filing date: Jan 13, 2005
• Grant date: Jun 2, 2015
• Expiry date: Mar 23, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/01
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A synthetic, soluble, endogenous complex formed from at least one component A and at least one component B, whereby component A comprises a binding domain for extra-cellular surface structures that internalize upon binding of component A of said complex, and component B has a constitutive catalytic kinase activity and effects cell biosynthesis/signalling including cell death after internalization. The complex allows to influence the growth and the physiology of cells. In particular said complex, nucleic acid molecules encoding it, cells transfected or transformed with these nucleic acid molecules are usable for the preparation of medicaments for the treatment of proliferative diseases, inflammatory diseases, allergies and autoimmune diseases.