Patent · US Active

Process for the stereoselective enzymatic reduction of keto compounds

US9045780B2 · kind B2 · utility

0Cited by

0References

8Claims

0Family size

Assignee

IEP GMBH · US

Inventors

Antje Gupta · Wiesbaden, DE
Maria Bobkova · Idstein, DE
Anke Tschentscher · Eltville am Rhein, DE

Key dates

Filing date	Mar 3, 2010
Grant date	Jun 2, 2015
Priority date	—
Expiry date	Mar 23, 2030

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02E50/10
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

In a process for the stereoselective, in particular enantioselective enzymatic reduction of keto compounds to the corresponding chiral hydroxy compounds, wherein the keto compounds are reduced with an enantioselective, NADH-specific oxidoreductase, a polypeptide is used for reducing the keto compounds, which polypeptide exhibits an R-ADH-signature H-[P; A]-[I; A; Q; V; L]-[G; K]-R at positions 204-208 and the following further structural features in their entirety:

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.