Method for production of particles of pharmaceutical substances and the use thereof

US9050254B2 · kind B2 · utility

Assignee

• Glatt GmbH · DE

Inventors

• Michael Jacob · Munich, DE
• Annette Grave · Binzen, DE
• Reinhard Nowak · Binzen, DE

Key dates

• Filing date: Oct 31, 2013
• Grant date: Jun 9, 2015
• Expiry date: Oct 31, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing particles with a length-width ratio of less than about 1.4 from a pharmaceutical substance, which method includes the following stages, that is: (a) provision of a melt of the pharmaceutical substance; (b) production of droplets of the melt by spraying into a processing chamber; (c) repeated guiding of solid particles past sprayed droplets in the processing chamber with the aid of a process gas jet which is guided in a defined way and whose temperature is fixed, depending on the solidification point of the melt, so that at least some of the droplets come into contact with particles and solidify thereon; (d) removal of particles from the processing chamber as a function of the particle size. The invention further relates to particles of pharmaceutical substances and the use thereof.