Dry powder formulations of particles that contain two or more active ingredients for treating obstructive or inflammatory airways diseases

US9050267B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Jeffry Weers · San Diego, US
• Nagaraja Rao · San Leandro, US
• Daniel Huang · Palo Alto, US
• Danforth Miller · Redwood City, US
• Thomas E. Tarara · San Diego, US

Key dates

• Filing date: Feb 3, 2012
• Grant date: Jun 9, 2015
• Expiry date: Feb 3, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5015
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dry powder formulations for inhalation comprising spray-dried particles and their use in the treatment of an obstructive or inflammatory airways disease. Each particle has a core of a first active ingredient in substantially crystalline form that is coated with a layer of a second active ingredient in substantially amorphous form that is dispersed in a pharmaceutically acceptable hydrophobic excipient. A process for preparing such formulations is also described.