Pyrrolotriazines as potassium ion channel inhibitors

US9050345B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Heather Finlay · Skillman, US
• Ashok Kumar Adisechan · Puducherry, IN
• Naveen Kumar Dhondi · Secunderabad, IN
• Kavitha Govindrajulu · Bengaluru, IN
• Prashantha Gunaga · Savanuru, IN
• John Lloyd · Yardley, US
• Pothukanuri Srinivasu · Bengaluru, IN

Key dates

• Filing date: Mar 7, 2014
• Grant date: Jun 9, 2015
• Expiry date: Mar 7, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I)wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, maintaining normal sinus rhythm, IKur-associated disorders, and other disorders mediated by ion channel function.