Patent · US Active

Pharmaceutical compositions comprising antisense oligonucleotides and methods of using same

US9050373B2 · kind B2 · utility

0Cited by
6References
27Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMay 13, 2010
Grant dateJun 9, 2015
Priority date—
Expiry dateJun 12, 2030

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2310/3233
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The invention provides compositions and associated methods for the antisense treatment of genetic disorders, infections and various other medical conditions. In particular, embodiments of the present invention are directed to pharmaceutical compositions comprising a combination of an antisense oligonucleotide compound conjugated with a positively charged polymer (“ON-PCP”) and a negatively charged polymer. Pharmaceutical compositions in accordance with the present invention have demonstrated improved antisense efficiency and reductions in cell toxicity compared to compositions that contain an oligonucleotide compound conjugated with a positively charged polymer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.