Piperazinyl cyclohexane compounds as GPR38 agonists

US9051255B2 · kind B2 · utility

Assignee

• DAIICHI SANKYO COMPANY, LIMITED · JP

Inventors

• Narihiro Toda · Tokyo, JP
• Rieko Takano · Tokyo, JP
• Takeshi Shida · Tokyo, JP
• Takahiro Katagiri · Tokyo, JP
• Mitsuhiro Iwamoto · Shinagawa, JP
• Shinji Ashida · Tokyo, JP
• Mami Yamazaki · Tokyo, JP

Key dates

• Filing date: Dec 27, 2013
• Grant date: Jun 9, 2015
• Expiry date: Dec 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

To find a therapeutic and/or prophylactic agent for gastrointestinal disorders and so on, the agent having excellent activity and high safety. A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof. In the formula, A represents an optionally substituted phenylene group; B represents an optionally substituted 4- to 10-membered heterocyclic group, an optionally substituted C6-C10 aryl group, or an optionally substituted C3-C10 cycloalkyl group; R1 represents a hydrogen atom or a C1-C3 alkyl group; R2 represents a hydrogen atom or a C1-C3 alkyl group; R3 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C3 alkoxy C1-C3 alkyl group, or a C1-C3 hydroxyalkyl group; R4 represents a hydrogen atom, a C1-C6 alkyl group, or a halogen atom; n represents an integer of 1 to 4; and X represents methylene, —O—, —NH—, —N(C1-C3 alkyl)-, —C(═O)—, —S—, —S(O)—, —S(O2)—, or a single bond.