Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy

US9051280B2 · kind B2 · utility

Assignees

• Abb Vie Deutschland Gmbh & Co. KG · DE
• Abb Vie Inc. · US

Inventors

• Udo Lange · Ludwigshafen, DE
• Wilhelm Amberg · Ludwigshafen, DE
• Michael Ochse · Wiesbaden, DE
• Berthold Behl · Ludwigshafen, DE
• Frauke Pohlki · Wiesbaden, DE
• Charles W. Hutchins · Libertyville, US

Key dates

• Filing date: Jul 11, 2012
• Grant date: Jun 9, 2015
• Expiry date: Jul 13, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to tetraline and indane derivatives of the formula (I)or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such tetraline and indane derivatives, and the use of such tetraline and indane derivatives for therapeutic purposes. The tetraline and indane derivatives are GlyT1 inhibitors.