Pyrido [2, 3-B] pyrazine compounds and their therapeutical uses such as for inhibiting ATP consuming proteins and treating diseases associated therewith

US9051318B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Dieter Dorsch · Ober-Ramstadt, DE
• Alfred Jonczyk · Darmstadt, DE
• Guenter Hoelzemann · Seeheim-Jugenheim, DE
• Christiane Amendt · Mühltal, DE
• Frank Zenke · Darmstadt, DE

Key dates

• Filing date: Feb 13, 2012
• Grant date: Jun 9, 2015
• Expiry date: Feb 23, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/048
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel pyrido[2,3-b]pyrazine compounds of formula (I):and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.