Protein charge regulator and protein-encapsulating polymer micelle complex
US9051354B2 · kind B2 · utility
3Cited by
2References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 17, 2009 |
| Grant date | Jun 9, 2015 |
| Priority date | — |
| Expiry date | Nov 9, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/645
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention comprises a cationic polymer having a polycation moiety and a charge-conversional protein whose overall charge is converted from basic or neutral to acidic by a specific charge regulator.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.