Human neutrophil gelatinase-associated lipocalin (hNGAL) muteins that bind hepcidin and nucleic acid encoding such

US9051382B2 · kind B2 · utility

Assignee

• Pieris AG · DE

Inventors

• Stefan Trentmann · Freising, DE
• Gabriele Matschiner · Munich, DE
• Arne Skerra · Freising, DE
• Andreas Hohlbaum · Paunzhausen, DE
• Martin Huelsmeyer · Freising, DE
• Hendrik Gille · Berlin, DE
• Hans-Juergen Christian · Moosburg an der Isar, DE
• Kristian Jensen · Munich, DE
• Rachida Siham Bel Aiba · Munich, DE

Key dates

• Filing date: Aug 16, 2011
• Grant date: Jun 9, 2015
• Expiry date: Dec 11, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2318/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Hepcidin, which proteins preferably are muteins of a lipocalin protein. The invention also relates to nucleic acid molecules encoding such proteins and to methods for generation and use of such proteins and nucleic acid molecules. Accordingly, the invention also is directed to pharmaceutical and/or diagnostic compositions comprising such a lipocalin proteins, including uses of these proteins.