Patent · US Active

Broad spectrum ErbB ligand binding molecules and methods for preparing and using them

US9051388B2 · kind B2 · utility

0Cited by
0References
3Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJan 27, 2012
Grant dateJun 9, 2015
Priority date—
Expiry dateJan 27, 2032

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Y207/10001
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Chimeric ErbB ligand binding molecules having detectable binding activity for more ErbB ligands than any one of native ErbB 1, ErbB3 or ErbB4 are disclosed. Preferably, the binding molecules bind a broad spectrum and, more preferably, the full spectrum of ErbB ligands. The chimeric ErbB ligand binding molecules generally have a subunit LI derived from one of ErbB1, 3, or 4 and a subunit LII derived from another distinct ErbB receptor type. The sub-domain, SI, which joins LI and LII can be from either one of the receptor types or can have portions from both. Pharmaceutical compositions that contain the molecules and methods for the treatment of ErbB sensitive diseases are also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.