Transdermal therapeutic system with high rate of utilization of active substance and dosing accuracy

US9056026B2 · kind B2 · utility

Assignee

• LTS Lohmann Therapie-Systeme AG · DE

Inventors

• Michael Horstmann · Neuwied, DE
• Walter Mueller · Andernach, DE

Key dates

• Filing date: Nov 9, 2007
• Grant date: Jun 16, 2015
• Expiry date: Feb 18, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/402
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Transdermal therapeutic system for administering at least one active pharmaceutical ingredient which is involatile at room temperature with a daily dose not exceeding 30 mg, comprising a backing layer which is impermeable for the active ingredient and faces away from the skin, an adjoining polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2, and a protective layer which can be detached from the skin-contact layer and is impermeable for the active ingredient.