Selective efflux inhibitors and related pharmaceutical compositions and methods of treatment
US9056111B1 · kind B1 · utility
1Cited by
1References
16Claims
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Key dates
| Filing date | Sep 19, 2012 |
| Grant date | Jun 16, 2015 |
| Priority date | — |
| Expiry date | Sep 19, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides pyrazolo[1,5-a]pyrimidine compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward ABCG2 over ABCB1. Compounds and compositions according to the present invention may be used to treat cancer, including drug resistant (DR) and multiple drug resistant (MDR) cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.