Peptide analogues of PA-IL and their utility for glycan and glycoconjugate analysis and purification
US9056904B2 · kind B2 · utility
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Key dates
| Filing date | Jul 2, 2013 |
| Grant date | Jun 16, 2015 |
| Priority date | — |
| Expiry date | Jul 2, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/765
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are peptide analogs of PA-IL and compositions containing them. The PA-IL peptide analogs have altered carbohydrate binding specificity relative to a PA-IL of SEQ ID NO:1, and thus the analogs contain amino acid substitutions in SEQ ID NO:1. The substitutions can be at positions 50, 52 and 53 of SEQ ID NO:1 and can include combinations of amino acid substitutions at those positions. Also included are methods for detecting changes in the glycosylation of carbohydrates and for separating biomolecules which contain glycoproteins or glycoconjugates.
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