Lov-D acyltransferase mediated acylation
US9057085B2 · kind B2 · utility
3Cited by
8References
29Claims
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Key dates
| Filing date | Sep 24, 2010 |
| Grant date | Jun 16, 2015 |
| Priority date | — |
| Expiry date | Mar 26, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.