Screening methods using G-protein coupled receptors and related compositions

US9057727B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• Chugai Pharmaceutical Co. · JP

Inventors

• Thomas J. Gardella · Needham, US
• John T. Potts, Jr. · Newton, US
• Masaru Shimizu · Shizuoka, JP
• Fumihiko Ichikawa · Tokyo, JP
• Harald Juppner · Cambridge, US
• Makoto Okazaki · Kawagoe, JP

Key dates

• Filing date: Sep 25, 2013
• Grant date: Jun 16, 2015
• Expiry date: Sep 25, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/726
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides.