Delivery system for sustained release of a calcium-channel blocking agent

US9060986B2 · kind B2 · utility

Assignee

• BDS Pharma GmbH · AT

Inventors

• Jorg Breitenbach · Mannheim, DE
• Bernd Liepold · Dossenheim, DE
• Didier Lefebvre · Mundelein, US
• Steffen Bossmann · Altleiningen, DE
• Benedikt Steitz · Macclesfield, GB
• Peter Hölig · Wächtersbach, DE

Key dates

• Filing date: Oct 5, 2010
• Grant date: Jun 23, 2015
• Expiry date: Oct 5, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A delivery system for sustained release of a calcium-channel blocking agent is adapted for introduction in the cerebrospinal fluid of a subject. The delivery system comprises a solid dispersion product of a calcium-channel blocking agent in a mixture of a (i) first poly(lactide-co-glycolide) having a molecular weight distribution centered around a first number average molecular weight Mn1 and a (ii) second poly(lactide-co-glycolide) having a molecular weight distribution centered around a second number average molecular weight Mn2, wherein Mn1 is in the range of from 2000 to 3000 g/mol and the ratio of Mn1/Mn2 is from 1.8 to 3.5. The delivery system is deposited in the vicinity of or adjacent to a blood vessel showing vasospasm or suspected of developing vasospasm.