Method for producing 1-amino-1-alkoxycarbonyl-2-vinylcyclopropane
US9061991B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 16, 2011 |
| Grant date | Jun 23, 2015 |
| Priority date | — |
| Expiry date | Feb 16, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
It is an object of the present invention to provide a novel method for producing (1R,2S)/(1S,2R)-1-amino-1-alkoxycarbonyl-2-vinylcyclopropane which is useful as a synthetic intermediate of therapeutic agents for hepatitis C and a synthetic intermediate thereof. According to the present invention, when a trans-2-butene derivative having a leaving group at each of the 1- and 4-positions is reacted with a malonic ester in the presence of a base, a specific amount of an alkali metal alkoxide or an alkali metal hydride is used as the base, and further a specific amount of a malonic ester is used to produce a cyclopropane diester, and further, chiral or achiral 1-amino-1-alkoxy-carbonyl-2-vinylcyclopropane and a salt thereof are synthesized using the cyclopropane diester.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.