Patent · US Active

Targeting the Rosa26 gene in human embryonic stem cells

US9062122B2 · kind B2 · utility

1Cited by

2References

13Claims

0Family size

Assignee

Mount Sinai School of Medicine of New York University · US

Inventors

Gordon Keller · Denver, US
Stefan Irion · Toronto, CA
Herve Luche · Ulm, DE
Paul Gadue · New York, US
Hans J. Fehling · Ulm, DE

Key dates

Filing date	Jan 18, 2008
Grant date	Jun 23, 2015
Priority date	—
Expiry date	Oct 31, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2840/44
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention provides a method for generating a transgenic eukaryotic cell population having a modified human Rosa26 locus, which method includes introducing a functional DNA sequence into the human Rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human Rosa26 locus. Finally, the invention provides an isolated DNA sequence corresponding to the human Rosa26 locus.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.