Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
US9066991B2 · kind B2 · utility
9Cited by
131References
54Claims
0Family size
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Key dates
| Filing date | Dec 22, 2010 |
| Grant date | Jun 30, 2015 |
| Priority date | — |
| Expiry date | Apr 4, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y203/02013
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Improved matrix or hydrogel that is formed by enzymatic crosslinking of polymers wherein the crosslinking enzyme molecules have been modified for the purpose of improving the crosslinking density, mechanical properties, or other properties of the matrix, and/or to provide improved control over the rate and/or extent of crosslinking, wherein the enzyme molecules are modified to alter the perceived volume of the enzyme molecules in the crosslinked matrix being formed. Methods of production and of use are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.