Intermediates of neutral endopeptidase inhibitors and preparation method thereof

US9067883B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• David Hook · Rheinfelden, CH
• Jianguang Zhou · 林湖乡, CN
• Yunzhong Li · 安丰镇, CN
• Jie Ku · Suzhou, CN

Key dates

• Filing date: Jan 21, 2011
• Grant date: Jun 30, 2015
• Expiry date: Sep 27, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/38
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a g-amino-d-biphenyl-a-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.