Inhibitors of protein kinases

US9067888B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Lutz Zeitlmann · Munich, DE
• Andre Niestroj · Halle (Saale), DE
• Ulrich Heiser · Halle (Saale), DE

Key dates

• Filing date: Aug 27, 2013
• Grant date: Jun 30, 2015
• Expiry date: Aug 27, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of general Formula (I):wherein R1, R2, R3, Ra, A, B and x are as defined herein are inhibitors of protein kinases in particular members of the cyclin-dependent kinase family and/or the glycogen synthase kinase 3 family and are useful in preventing and/or treating any type of pain, inflammatory disorders, cancer, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases, metabolic disorders, renal diseases, neurologic and neuropsychiatric diseases and neurodegenerative diseases.