Biphenylcarboxamides as ROCK kinase inhibitors

US9067889B2 · kind B2 · utility

Assignee

• Amakem NV · BE

Inventors

• Jo Alen · Averbode, BE
• Sandro Boland · Diepenbeek, BE
• Arnaud Pierre Jean Bourin · Diepenbeek, BE
• Olivier Defert · Diepenbeek, BE
• Dirk Leysen · Diepenbeek, BE

Key dates

• Filing date: Aug 31, 2012
• Grant date: Jun 30, 2015
• Expiry date: Aug 31, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases, gastrointestinal diseases and respiratory diseases.