Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [ (S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl ]-amide

US9067918B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Olaf Ritzeler · Bad Soden, DE
• Mandy Mohnicke · Frankfurt am Main, DE
• Guenter Billen · Frankfurt am Main, DE
• Bruno Baumgartner · Frankfurt am Main, DE
• Martin Brockelmann · Frankfurt am Main, DE
• Norbert Nagel · Frankfurt am Main, DE

Key dates

• Filing date: Dec 4, 2012
• Grant date: Jun 30, 2015
• Expiry date: Dec 4, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to polymorphs and hydrates of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [(S)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide, processes for their preparation and their use, in particular in pharmaceutical compositions.