Thiocarbon-protecting groups for RNA synthesis

US9067961B2 · kind B2 · utility

Assignees

• AGILENT TECHNOLOGIES, INC. · US
• The Regents of the University of Colorado Denver · US

Inventors

• Douglas J. Dellinger · Boulder, US
• Agnieszka Sierzchala · Boulder, US
• John Turner · Berlin, DE
• Joel Myerson · Berkeley, US
• Zoltan Kupihar · Szeged, HU
• Fernando Ferreira · Loveland, US
• Marvin H. Caruthers · Boulder, US
• Geraldine F. Dellinger · Boulder, US

Key dates

• Filing date: May 31, 2012
• Grant date: Jun 30, 2015
• Expiry date: May 10, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Aspects of the invention include 2′ protected nucleoside monomers that are protected at the 2′ site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.