Neisserial antigenic peptides

US9067987B2 · kind B2 · utility

Assignee

• GLAXOSMITHKLINE BIOLOGICALS SA · BE

Inventors

• Cesira Galeotti · Poggibonsi, IT
• Guido Grandi · Segrate, IT
• Vega Masignani · Siena, IT
• Marirosa Mora · Siena, IT
• Mariagrazia Pizza · Siena, IT
• Rino Rappuoli · Siena, IT
• Guilio Ratti · Siena, IT
• Vincenzo Scarlato · Siena, IT
• Maria Scarselli · Siena, IT

Key dates

• Filing date: Feb 24, 2012
• Grant date: Jun 30, 2015
• Expiry date: Feb 24, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.