Hydrolytically decomposable ionic copolymers

US9068065B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Andreas Greiner · Amöneburg, DE
• Seema Agarwal · Marburg, DE
• Thomas Kissel · Staufen, DE
• Liqun Ren · Mannheim, DE

Key dates

• Filing date: Apr 9, 2009
• Grant date: Jun 30, 2015
• Expiry date: Sep 11, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F2800/10
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

The invention at hand provides hydrolytically degradable ionic copolymers. These ionic copolymerizates are composed of one cyclic ketene acetal A, one anionic or cationic methacrylic acid derivative B, selected from 2-methyl-methacrylate, [2-(2-methyl-1-methylene-allyloxy)]ethanesulfonate, [2-(2-methyl-1-methylene-allyloxy)ethyl]phosphonate or a quaternary amine of the N,N-dimethylaminoethylmethacrylic acid (DMAEMA) and, optionally, a neutral methacrylic acid derivative C.The hydrolytically degradable anionic copolymers according to the present invention are produced by polymerizing the components A, B and C in the presence of a radical initiator under inert gas atmosphere and subsequent purification.All copolymers according to the present invention are hydrolytically degradable. Copolymers comprising a maximum of 40 mol-% of ester groups in the backbone are additionally biodegradable, wherein in the case of cationic copolymers a maximum of 20 mol-% of quaternized DMAEMA is allowed to be available.Cationic copolymers comprising at least 50 mol-% of the component B are antimicrobial.Both anionic as well as cationic copolymers are suitable for producing nanoparticles. Cationic copoly…