Measurement and monitoring of cell clonality
US9068224B2 · kind B2 · utility
4Cited by
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4Claims
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Key dates
| Filing date | Jan 6, 2014 |
| Grant date | Jun 30, 2015 |
| Priority date | — |
| Expiry date | Jan 6, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/106
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods are provided for the detection and analysis of clonality in a cell population, where parallel sequencing is applied to a nucleic acid sample obtained from the cell population, optionally a population of lymphocytes. Replicate samples are amplified, and sequenced, where identification of coincident sequences in two or more replicates is indicative of clonal expansion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.