Structural model of G protein-coupled receptor and method for designing ligand capable of binding to G protein-coupled receptor using the structural model
US9069700B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Dec 3, 2012 |
| Grant date | Jun 30, 2015 |
| Priority date | — |
| Expiry date | Dec 3, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2299/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a method for constructing a three-dimensional structural model of an activated intermediate of a G protein-coupled protein receptor (GPCR) or a complex between a GPCR and a ligand. The three-dimensional structural model may be used to identify, screen, search, evaluate, or design GPCR agonists or antagonists. In a representative embodiment, a three-dimensional structural model of a photoactivated intermediate of rhodopsin is constructed using molecule modeling software and structural coordinates of the crystal structure of rhodopsin. The three-dimensional structural model of rhodopsin is subsequently used to construct structural models of activated intermediates of other GPCRs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.