Enhancement of bone morphogenic protein (BMP) retention with BMP binding peptide (BBP)

US9072709B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS · US

Inventors

• Samuel S. Murray · Santa Clarita, US
• Elsa J. Murray · Santa Clarita, US
• Jeffrey C. Wang · West Hollywood, US
• Keyvan Behnam · Simi Valley, US

Key dates

• Filing date: Jun 23, 2010
• Grant date: Jul 7, 2015
• Expiry date: Oct 10, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P19/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The use of autogenous bone graft is the current gold standard in the 1.5 million bone-grafting surgeries performed annually in the United States. Although this practice has resulted in high rates of fusion success, it is associated with increased operative time and blood loss, along with a significant degree of donor-site morbidity. Additionally, in certain settings such as revision cases, multilevel constructs, or in patients with medical comorbidities, autogenous bone graft may exist in limited quantity and quality. This significant need for a suitable alternative to autogenous bone graft has stimulated great interest in the exploration of bone graft substitutes and extenders.