Long-acting glucagon conjugate and pharmaceutical composition comprising the same for the prevention and treatment of obesity
US9072794B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 21, 2011 |
| Grant date | Jul 7, 2015 |
| Priority date | — |
| Expiry date | Sep 28, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/605
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a novel long-acting glucagon conjugate in which glucagon or its derivative is covalently linked to a polymer carrier via a non-peptide linker, and a pharmaceutical composition comprising the same as an effective ingredient useful for the prevention and treatment of obesity. Since the long-acting glucagon conjugate of the present invention shows improved in vivo durability and stability, when used in combination with an anti-obesity drug, it is possible to induce synergistic effects on the loss of body weight and decrease in food intake without causing any side-effects such as fluctuation in blood glucose level. Accordingly, the long-acting peptide conjugate of the present invention is very effective for the prevention and treatment of obesity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.